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KMID : 0923620210210010006
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Immune Network
2021 Volume.21 No. 1 p.6 ~ p.6
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Adenovirus Vectors: Excellent Tools for Vaccine Development
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Chang Jun
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Abstract
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Adenovirus was originally used as a vector for gene therapy. In recent years, with the development of the next-generation vectors with increased safety and high immunogenicity to transgene products, its utility as a vaccine vector has continued to increase. Adenovirus-based vaccines are currently being tested not only to prevent various infectious diseases but also to be applied as cancer vaccines. In this review, I discuss the innate and adaptive aspects of the immunological characteristics of adenovirus vectors and further examine the current status of advanced adenovirus-based vaccine development. Various methods that can overcome the limitations of currently used adenoviruses as vaccine vehicles are also discussed. Through this study, I hope that vaccine development using adenovirus vectors will be expedited and more successful.
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KEYWORD
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Adenovirus, Genetic vector, Adenovector, Vaccine
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